验证数据展示
产品信息
18067-1-PBS targets KCNA1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag12699 Product name: Recombinant human KCNA1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-163 aa of BC101733 Sequence: MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESS 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) |
| 别名 | AEMK, EA1, HBK1, HUK1, KV1.1 |
| 计算分子量 | 495 aa, 56 kDa |
| 观测分子量 | 86 kDa |
| GenBank蛋白编号 | BC101733 |
| 基因名称 | KCNA1 |
| Gene ID (NCBI) | 3736 |
| RRID | AB_3741943 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q09470 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Potassium voltage-gated channel subfamily A member 1 (KCNA1, also known as Kv1.1) is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PMID: 19903818; 8845167). KCNA1 expression was reduced in human cancers, and this decrease correlated with an increase in breast cancer aggressiveness (PMID: 23774215). Furthermore, Kv1.1 is expressed in the brain as a mature glycoprotein, which is reported to be 86 kDa (PMID: 16305740).
