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验证数据展示

  • WB analysis using 25533-1-AP (same clone as 25533-1-PBS)

    WB analysis using 25533-1-AP (same clone as 25533-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 25533-1-AP (KANSL3 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25533-1-PBS in a different storage buffer formulation.

  • IHC staining of human intrahepatic cholangiocarcinoma using 25533-1-AP (same clone as 25533-1-PBS)

    IHC staining of human intrahepatic cholangiocarcinoma using 25533-1-AP (same clone as 25533-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human intrahepatic cholangiocarcinoma tissue slide using 25533-1-AP (KANSL3 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25533-1-PBS in a different storage buffer formulation.

  • IHC staining of human intrahepatic cholangiocarcinoma using 25533-1-AP (same clone as 25533-1-PBS)

    IHC staining of human intrahepatic cholangiocarcinoma using 25533-1-AP (same clone as 25533-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human intrahepatic cholangiocarcinoma tissue slide using 25533-1-AP (KANSL3 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25533-1-PBS in a different storage buffer formulation.

KANSL3 Polyclonal antibody, PBS Only

KANSL3 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 25533-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

KIAA1310, KAT8 regulatory NSL complex subunit 3, PRTD, NSL3, NSL complex protein NSL3

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

25533-1-PBS targets KANSL3 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag22117

Product name: Recombinant human KIAA1310 protein

Source: e coli.-derived, PET30a

Tag: 6*His

Domain: 530-878 aa of BC063792

Sequence: LSSVSSSPTSSPKTKVTTVTSAQKSSQIGSSQLLKRHVQRTEAVLTHKQAQVPISSEPPEEGEKEDLRVQLKRHHPSSPLPGSKTSKRPKIKVSLISQGDTAGGPCAPSQGSAPEAAGGKPITMTLGQASAGAKELTGLLTTAKSSSSEGGVSASPVPSVVSSSTAPSALHTLQSRLVATSPGSSLPGATSASSLLQGLSFSLQDISSKTSGLPANPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGGLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGAAPSEESSSQVLPSSSQRLPPAP

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 KIAA1310
别名 KIAA1310, KAT8 regulatory NSL complex subunit 3, PRTD, NSL3, NSL complex protein NSL3
计算分子量 878 aa, 93 kDa
观测分子量105 kDa
GenBank蛋白编号BC063792
基因名称 KANSL3
Gene ID (NCBI) 55683
RRIDAB_3085802
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9P2N6
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

KANSL3, or KAT8-associated nonspecific lethal complex subunit 3, is a component of the KANSL complex, which is an important chromatin modifier in higher animals. This complex plays a crucial role in regulating housekeeping genes and is highly conserved across species. KANSL3, along with other KANSL complex members, is essential for cell division and has been shown to interact robustly both in vitro and in vivo. KANSL3 has been found to have a dual role in cellular function. In interphase, KANSL3 is chromatin-bound and regulates the expression of housekeeping genes. During mitosis, KANSL3 relocates to the mitotic spindle and is important for cell division. It has been identified as a microtubule minus-end-binding protein, which is a novel function for a chromatin-binding complex. KANSL3's ability to bind directly to microtubule minus ends is significant, as very few proteins are known to perform this function.

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