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验证数据展示

  • IHC staining of human kidney using 17670-1-AP (same clone as 17670-1-PBS)

    IHC staining of human kidney using 17670-1-AP (same clone as 17670-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 17670-1-AP (JAK2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17670-1-PBS in a different storage buffer formulation.

  • WB analysis of NIH/3T3 using 17670-1-AP (same clone as 17670-1-PBS)

    WB analysis of NIH/3T3 using 17670-1-AP (same clone as 17670-1-PBS)

    NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 17670-1-AP (JAK2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17670-1-PBS in a different storage buffer formulation.

  • IP experiment of NIH/3T3 using 17670-1-AP (same clone as 17670-1-PBS)

    IP experiment of NIH/3T3 using 17670-1-AP (same clone as 17670-1-PBS)

    IP result of anti-JAK2 (IP:17670-1-AP, 4ug; Detection:17670-1-AP 1:300) with NIH/3T3 cells lysate 3440 ug. This data was developed using the same antibody clone with 17670-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 17670-1-AP (same clone as 17670-1-PBS)

    IHC staining of human kidney using 17670-1-AP (same clone as 17670-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 17670-1-AP (JAK2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17670-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

JAK2 Polyclonal antibody, PBS Only

JAK2 Polyclonal Antibody for WB, IHC, IP, ELISA
Cat No. 17670-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IP, ELISA

别名

Tyrosine protein kinase JAK2, JTK10, Janus kinase 2, JAK-2, JAK 2

缓冲液配方: 
偶联物:  Unconjugated
规格价格库存

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产品信息

17670-1-PBS targets JAK2 in WB, IHC, IP, ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IP, ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag11264

Product name: Recombinant human JAK2 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 764-1129 aa of BC039695

Sequence: EDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 Janus kinase 2 (a protein tyrosine kinase)
别名 Tyrosine protein kinase JAK2, JTK10, Janus kinase 2, JAK-2, JAK 2
计算分子量 1132 aa, 130 kDa
观测分子量 120-130 kDa
GenBank蛋白编号BC039695
基因名称 JAK2
Gene ID (NCBI) 3717
RRIDAB_2811138
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO60674
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Janus kinases (JAKs) are non-receptor tyrosine kinases that are activated by cytokine binding to cytokine receptors resulting in stimulation of the JAK-STAT signaling pathway. Aberrant activation of this signaling pathway is associated with numerous immune disorders and cancer.

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