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验证数据展示

  • WB analysis using 30703-1-AP (same clone as 30703-1-PBS)

    WB analysis using 30703-1-AP (same clone as 30703-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30703-1-AP (Integrin alpha 2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30703-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 30703-1-AP (same clone as 30703-1-PBS)

    IHC staining of human colon cancer using 30703-1-AP (same clone as 30703-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer slide using 30703-1-AP (Integrin alpha 2 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30703-1-PBS in a different storage buffer formulation.

  • IF Staining of A431 using 30703-1-AP (same clone as 30703-1-PBS)

    IF Staining of A431 using 30703-1-AP (same clone as 30703-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed A431 cells using ITGA2 antibody (30703-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 30703-1-PBS in a different storage buffer formulation.

CD49b Polyclonal antibody, PBS Only

CD49b Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 30703-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

ITGA2, BR, Collagen receptor, GPIa, Integrin alpha 2

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

30703-1-PBS targets CD49b in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag32771

Product name: Recombinant human ITGA2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 840-1132 aa of NM_002203

Sequence: GIVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSFEDVGPKFIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPT

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
别名 ITGA2, BR, Collagen receptor, GPIa, Integrin alpha 2
计算分子量126 kDa
观测分子量140-150 kDa
GenBank蛋白编号NM_002203
基因名称 Integrin alpha 2
Gene ID (NCBI) 3673
RRIDAB_3669752
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP17301
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-2 (ITGA2, CD49b) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor (VLA-2) for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin.

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