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验证数据展示

  • WB analysis of A431 using 66906-1-Ig (same clone as 66906-1-PBS)

    WB analysis of A431 using 66906-1-Ig (same clone as 66906-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 66906-1-Ig (Integrin alpha-6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66906-1-PBS in a different storage buffer formulation.

Integrin alpha 6 Monoclonal antibody, PBS Only

Integrin alpha 6 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 66906-1-PBS

产品说明书

CloneNo. 2B12A1

宿主/亚型

Mouse / IgG2b

种属反应性

human

应用

WB, Indirect ELISA

别名

ITGA6, 2B12A1, CD49 antigen-like family member F, CD49f, Integrin alpha-6

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

66906-1-PBS targets Integrin alpha 6 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原 Integrin alpha 6 fusion protein Ag25866 种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 integrin, alpha 6
别名 ITGA6, 2B12A1, CD49 antigen-like family member F, CD49f, Integrin alpha-6
计算分子量 1073 aa, 119 kDa
观测分子量 115-120 kDa
GenBank蛋白编号BC136456
基因名称 Integrin alpha 6
Gene ID (NCBI) 3655
RRIDAB_2882233
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP23229
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha 6 (ITGA6, also known as CD49f or VLA-6) is a 120-kDa single-pass type 1 transmembrane glycoprotein, which combines with the beta 1 subunit (ITGB1, CD29) or beta 4 subunit (ITGB4, CD104) to form heterodimeric laminin receptors (PMID: 1976638; 2351695). Integrin alpha 6 mediates cell-to-cell and cell-to-stroma adhesion. It has also been found in many different stem cell populations and is involved in homing and connecting stem cells to their niches and regulating self-renewal mechanisms in stem cells (PMID: 28494695).