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验证数据展示

  • IHC staining of mouse brain using 12816-1-AP (same clone as 12816-1-PBS)

    IHC staining of mouse brain using 12816-1-AP (same clone as 12816-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 12816-1-AP (ITPKB antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12816-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 12816-1-AP (same clone as 12816-1-PBS)

    IHC staining of mouse brain using 12816-1-AP (same clone as 12816-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 12816-1-AP (ITPKB antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12816-1-PBS in a different storage buffer formulation.

  • WB analysis of mouse brain using 12816-1-AP (same clone as 12816-1-PBS)

    WB analysis of mouse brain using 12816-1-AP (same clone as 12816-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 12816-1-AP (ITPKB antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12816-1-PBS in a different storage buffer formulation.

  • IHC staining of human cervical cancer using 12816-1-AP (same clone as 12816-1-PBS)

    IHC staining of human cervical cancer using 12816-1-AP (same clone as 12816-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 12816-1-AP (ITPKB Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 12816-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

ITPKB Polyclonal antibody, PBS Only

ITPKB Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 12816-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

12816-1-PBS targets ITPKB in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag3456

Product name: Recombinant human ITPKB protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-350 aa of BC015009

Sequence: MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRAHSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 inositol 1,4,5-trisphosphate 3-kinase B
别名
计算分子量 946 aa, 102 kDa
观测分子量 102-110 kDa
GenBank蛋白编号BC015009
基因名称 ITPKB
Gene ID (NCBI) 3707
RRIDAB_2129846
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP27987
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Inositol 1,4,5-trisphosphate 3-kinase isoform B (IITPKB) is also named as IP3KB and possesses important roles in the development of immune cells. IP3KB can be targeted to multiple cellular compartments, among them nuclear localization and binding in close proximity to the plasma membrane. The B isoform is the only IP3K that is almost ubiquitously expressed in mammalian cells(PMID:21148483).Three isoforms of IP3KB occur in mammals, which are distinguished by different molecular masses, sensitivity to Ca2+/CaM(calmodulin), intracellular distribution and tissue expression (PMID:16173920). ITPKB can be cleaved into many fragments, this antibody can recognize the N-terminal peptide fragment.(PMID:15130091)

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