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验证数据展示

  • WB analysis using 20702-1-AP (same clone as 20702-1-PBS)

    WB analysis using 20702-1-AP (same clone as 20702-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 20702-1-AP (IRS2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20702-1-PBS in a different storage buffer formulation.

  • WB analysis using 20702-1-AP (same clone as 20702-1-PBS)

    WB analysis using 20702-1-AP (same clone as 20702-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20702-1-AP (IRS2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20702-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse skeletal muscle using 20702-1-AP (same clone as 20702-1-PBS)

    IHC staining of mouse skeletal muscle using 20702-1-AP (same clone as 20702-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 20702-1-AP (IRS2 antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 20702-1-PBS in a different storage buffer formulation.

IRS2 Polyclonal antibody, PBS Only

IRS2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 20702-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

Insulin receptor substrate 2, IRS 2, IRS-2

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

20702-1-PBS targets IRS2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 IRS2
别名 Insulin receptor substrate 2, IRS 2, IRS-2
计算分子量 137 kDa
观测分子量150-185 kDa
GenBank蛋白编号NM_003749
基因名称 IRS2
Gene ID (NCBI) 8660
RRIDAB_2918067
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9Y4H2
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The family of INS receptor substrates (IRS) consists of four proteins (IRS-1-IRS-4), which were initially characterized as typical cytosolic adaptor proteins involved in INS receptor (IR) and INS-like growth factor I receptor (IGF-IR) signaling. Impaired glucose tolerance and INS resistance, and thus type 2 diabetes were demonstrated in Irs2 knockout mice. In vivo data also indicated that he regulation of beta-cell mass involves IRS2, while IRS1 is only required for proper INS production in beta-cells. IRS2, like IRS1, has a predicted molecular weight of 137 kDa, however, as a result of its extensive serine phosphorylation it separates on a SDS-PAGE as a band of approximately 150-185 kDa.

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