验证数据展示
Planning an IHC experiment? We recommend our IHCeasy ING2 Ready-To-Use IHC Kit. ING2 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 66512-1-Ig
产品信息
CL488-66512 targets ING2 in applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 | ING2 fusion protein Ag19291 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | inhibitor of growth family, member 2 |
| 别名 | p32, Inhibitor of growth protein 2, Inhibitor of growth 1-like protein, ING1Lp, ING1L |
| 计算分子量 | 280 aa, 33 kDa |
| 观测分子量 | 33-35 kDa |
| GenBank蛋白编号 | BC030128 |
| 基因名称 | ING2 |
| Gene ID (NCBI) | 3622 |
| 偶联类型 | CoraLite® Plus 488 Fluorescent Dye |
| 最大激发/发射波长 | 493 nm / 522 nm |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q9H160 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3 |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ING2, also named as ING1L, belongs to the ING family and contains a PHD-type zinc finger. As a candidate tumor suppressor, ING2 seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. It is a component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. Recent finding reported that ING2 regulates muscle differentiation by regulating chormatin remodeling program.