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验证数据展示

  • FC experiment of rat splenocytes using 98046-1-RR (same clone as 98046-1-PBS)

    FC experiment of rat splenocytes using 98046-1-RR (same clone as 98046-1-PBS)

    1x10^6 unstimulated or PMA, Ionomycin and Brefeldin A treated rat splenocytes were intracellularly stained with APC Anti-Rat CD4 (OX-35) and 0.25 ug Anti-Rat IL-2 Rabbit Recombinant Antibody (98046-1-RR, Clone: 240264C7) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer. This data was developed using the same antibody clone with 98046-1-PBS in a different storage buffer formulation.

  • FC experiment of rat splenocytes using 98046-1-RR (same clone as 98046-1-PBS)

    FC experiment of rat splenocytes using 98046-1-RR (same clone as 98046-1-PBS)

    1x10^6 PMA, Ionomycin and Brefeldin A treated rat splenocytes were intracellularly stained with 0.25 ug Anti-Rat IL-2 Rabbit Recombinant Antibody (98046-1-RR, Clone: 240264C7) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (red), or 0.25 ug Isotype Control (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer. This data was developed using the same antibody clone with 98046-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98046-1-RR

    Affinity and Kinetic Characterization of 98046-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98046-1-RR against Rat IL2 were performed. The affinity constant is 0.36 nM.

Anti-Rat IL-2 Rabbit Recombinant Antibody, PBS Only

IL-2 Uni-rAb® Recombinant Antibody for FC (Intra)
Cat No. 98046-1-PBS

产品说明书

CloneNo. 240264C7

宿主/亚型

Rabbit / IgG

种属反应性

rat

应用

FC (Intra)

别名

Il2, 240264C7, interleukin 2

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98046-1-PBS targets IL-2 in FC (Intra) applications and shows reactivity with rat samples.

经测试应用 FC (Intra) Application Description
经测试反应性 rat
免疫原

CatNo: Eg0260

Product name: Recombinant Rat IL-2 protein (His Tag)

Source: mammalian cells-derived, pHZ-KIsec-C-6*HIS

Tag: C-6*HIS

Domain: 21-155 aa of NM_053836

Sequence: MAPTSSPAKETQQHLEQLLLDLQVLLRGIDNYKNLKLPMMLTFKFYLPKQATELKHLQCLENELGALQRVLDLTQSKSFHLEDAGNFISNIRVTVVKLKGSENKFECQFDDEPATVVEFLRRWIAICQSIISTMTQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 2
别名 Il2, 240264C7, interleukin 2
计算分子量18 kDa
GenBank蛋白编号NM_053836
基因名称 Il2
Gene ID (NCBI) 116562
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP17108
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-2 (IL-2) is a four-helix bundle, type I cytokine that functions as a growth factor for a wide range of leukocytes. In the immune system, IL-2 is essential for immune homeostasis, normal T regulatory cell function, and self-tolerance. It regulates immune cell homeostasis and has been used to treat a range of disorders including cancer and autoimmune disease. IL-2 signals through heterodimerization of the IL-2Rβ and IL-2Rγ receptor subunits (PMID: 25992858, 24907378, 15034008, 17981641).

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