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验证数据展示

  • WB analysis of NK-92 using 84390-5-RR

    WB analysis of NK-92 using 84390-5-RR

    NK-92 cells were subjected to SDS PAGE followed by western blot with 84390-5-RR (IL18R1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

  • IF Staining of NK-92 using 84390-5-RR

    IF Staining of NK-92 using 84390-5-RR

    Immunofluorescent analysis of (4% PFA) fixed NK-92 cells using IL-18R1/CD218a antibody (84390-5-RR, Clone: 241673G6 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2).

  • Affinity and Kinetic Characterization of 84390-5-RR

    Affinity and Kinetic Characterization of 84390-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84390-5-RR against Human IL-18R1/CD218a were performed. The affinity constant is 0.948 nM.

IL-18R1/CD218a Recombinant monoclonal antibody

IL-18R1/CD218a Recombinant Antibody for WB, IF/ICC, ELISA
Cat No. 84390-5-RR

产品说明书

CloneNo. 241673G6

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, ELISA

别名

IL18R1, IL 18R1, IL 18R 1, EC:3.2.2.6, CD218a

缓冲液配方:  PBS, Azide, Glycerol
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
Unconjugated
规格价格库存

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经过测试的应用

Positive WB detected inNK-92 cells
Positive IF/ICC detected inNK-92 cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:2000
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

84390-5-RR targets IL-18R1/CD218a in WB, IF/ICC, ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, ELISA Application Description
经测试反应性 human
免疫原

Recombinant Protein

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 18 receptor 1
别名 IL18R1, IL 18R1, IL 18R 1, EC:3.2.2.6, CD218a
计算分子量 541 aa, 62 kDa
观测分子量60-75 kDa
GenBank蛋白编号BC093975
基因名称 IL18R1
Gene ID (NCBI) 8809
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ13478
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

IL-18R1 (CD218a) is a component of the interleukin-18 receptor (IL-18R) complex, which is critical for the signaling of IL-18, a pro-inflammatory cytokine. This receptor complex, consisting of IL-18R1 and the IL-18 receptor accessory protein (IL-18RAP), belongs to the immunoglobulin-like family of interleukin-1 receptors (PMID: 35461924). IL-18R1 plays a significant role in inducing the production of interferon-gamma (IFN-γ) and other inflammatory cytokines, contributing to innate and adaptive immune responses (PMID: 2550053). It is also suggested to play a role in hypertension and chronic kidney disease, where the IL-18/IL-18R1 signaling axis may have diagnostic and therapeutic potential (PMID: 35461924).

实验方案

Product Specific Protocols
IF protocol for IL-18R1/CD218a antibody 84390-5-RRDownload protocol
WB protocol for IL-18R1/CD218a antibody 84390-5-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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