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验证数据展示

  • WB analysis of human peripheral blood platelets using 84948-5-RR (same clone as 84948-5-PBS)

    WB analysis of human peripheral blood platelets using 84948-5-RR (same clone as 84948-5-PBS)

    human peripheral blood platelets were subjected to SDS PAGE followed by western blot with 84948-5-RR (IL-5 R alpha/CD125 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84948-5-PBS in a different storage buffer formulation.

  • IF Staining of MC/9 using 84948-5-RR (same clone as 84948-5-PBS)

    IF Staining of MC/9 using 84948-5-RR (same clone as 84948-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed MC/9 cells using IL-5RA/CD125 antibody (84948-5-RR, Clone: 242234H8 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84948-5-PBS in a different storage buffer formulation.

IL-5RA/CD125 Recombinant monoclonal antibody, PBS Only

IL-5RA/CD125 Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 84948-5-PBS

产品说明书

CloneNo. 242234H8

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

IL5RA, 242234H8, CD125, HSIL5R3, IL 5 receptor subunit alpha

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84948-5-PBS targets IL-5RA/CD125 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Eg1665

Product name: Recombinant Human IL-5RA/CD125protein (rFc Tag)

Source: mammalian cells-derived, pHZ-KIsec-C-rFc

Tag: C-rFc

Domain: 21-335 aa of NM_175726.4

Sequence: DLLPDEKISLLPPVNFTIKVTGLAQVLLQWKPNPDQEQRNVNLEYQVKINAPKEDDYETRITESKCVTILHKGFSASVRTILQNDHSLLASSWASAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQYFLYYRYGSWTEECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPFDQLFALHAIDQINPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQIEKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGNDE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 5 receptor, alpha
别名 IL5RA, 242234H8, CD125, HSIL5R3, IL 5 receptor subunit alpha
计算分子量48 kDa
观测分子量60 kDa
GenBank蛋白编号NM_175726.4
基因名称 IL-5RA/CD125
Gene ID (NCBI) 3568
RRIDAB_3743874
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ01344-1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-5 receptor subunit alpha (IL-5RA), also known as CD125, is a type I transmembrane protein that belongs to the type I cytokine receptor family. IL-5RA is a critical component of the high-affinity IL-5 receptor complex, IL-5R, which consists of the alpha chain (IL-5RA) that specifically binds to IL-5 and the common beta chain (CD131) shared with receptors for IL-3 and GM-CSF (PMID: 1833065; 7872157). IL-5/IL-5RA signaling axis is crucial for the differentiation, proliferation, recruitment, and activation of eosinophils, and is also involved in pathological eosinophilia (PMID: 34638583).

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