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验证数据展示

  • FC experiment of C57BL/6 Th2-polarized splenocytes using 98352-1-RR (same clone as 98352-1-PBS)

    FC experiment of C57BL/6 Th2-polarized splenocytes using 98352-1-RR (same clone as 98352-1-PBS)

    1x10^6 untreated or PMA, Ionomycin and Brefeldin A treated C57BL/6 Th2-polarized splenocytes were intracellularly stained with 0.125 ug Anti-Mouse IL5 Rabbit RecAb (98352-1-RR, Clone:242075A7) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Mouse CD4 (GK1.5) (APC-65104, Clone: GK1.5). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98352-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98352-1-RR

    Affinity and Kinetic Characterization of 98352-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98352-1-RR against Mouse IL-5 were performed. The affinity constant is 5.79 nM.

Anti-Mouse IL-5 Rabbit Recombinant Antibody, PBS Only

IL-5 Uni-rAbTM Recombinant Antibody for FC (Intra)
Cat No. 98352-1-PBS

产品说明书

CloneNo. 242075A7

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC (Intra)

别名

Il5, Il 5, interleukin 5, interleukin-5

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98352-1-PBS targets IL-5 in FC (Intra) applications and shows reactivity with mouse samples.

经测试应用 FC (Intra) Application Description
经测试反应性 mouse
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 5
别名 Il5, Il 5, interleukin 5, interleukin-5
计算分子量 15 aa
GenBank蛋白编号NM_010558
基因名称 Il5
Gene ID (NCBI) 16191
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP04401
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-5 (IL-5) is a critical cytokine that regulates the growth, activation, and survival of eosinophils. IL-5 is produced by both hematopoietic and non-hematopoietic cells including T cells, granulocytes, and natural helper cells. IL-5 exerts its effects for proliferation and differentiation via receptors that comprise an IL-5-specific α and common β-subunit. Overexpression of IL-5 in vivo significantly increases eosinophils and B cells in number, while mice lacking a functional gene for IL-5 or IL-5 receptor display a number of developmental and functional impairments in B cells and eosinophil lineages.