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验证数据展示

  • IHC staining of mouse spleen using 84758-5-RR (same clone as 84758-5-PBS)

    IHC staining of mouse spleen using 84758-5-RR (same clone as 84758-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 84758-5-RR (IL-4RA/CD124 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84758-5-PBS in a different storage buffer formulation.

  • IHC staining of human tonsil using 84758-5-RR (same clone as 84758-5-PBS)

    IHC staining of human tonsil using 84758-5-RR (same clone as 84758-5-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsil tissue slide using 84758-5-RR (IL-4RA/CD124 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84758-5-PBS in a different storage buffer formulation.

  • IHC staining of rat spleen using 84758-5-RR (same clone as 84758-5-PBS)

    IHC staining of rat spleen using 84758-5-RR (same clone as 84758-5-PBS)

    Immunohistochemical analysis of paraffin-embedded rat spleen tissue slide using 84758-5-RR (IL-4RA/CD124 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84758-5-PBS in a different storage buffer formulation.

  • WB analysis of NIH/3T3 using 84758-5-RR (same clone as 84758-5-PBS)

    WB analysis of NIH/3T3 using 84758-5-RR (same clone as 84758-5-PBS)

    NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 84758-5-RR (IL-4 R alpha/CD124 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84758-5-PBS in a different storage buffer formulation.

Mouse IL-4RA/CD124 Recombinant monoclonal antibody, PBS Only

IL-4RA/CD124 Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 84758-5-PBS

产品说明书

CloneNo. 242262E3

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

242262E3, CD124, IL-4 receptor subunit alpha, Il4r, IL-4R subunit alpha

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84758-5-PBS targets IL-4RA/CD124 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Eg2176

Product name: Recombinant Mouse IL-4RA/CD124 protein (rFc Tag)(HPLC verified)

Source: mammalian cells-derived, pHZ-KIsec-C-rFc

Tag: C-rFc

Domain: 26-233 aa of NM_001008700.3

Sequence: IKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 4 receptor, alpha
别名 242262E3, CD124, IL-4 receptor subunit alpha, Il4r, IL-4R subunit alpha
计算分子量88 kDa
观测分子量130 kDa
GenBank蛋白编号NM_001008700.3
基因名称 Il4ra
Gene ID (NCBI) 16190
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP16382-1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IL-4 receptor alpha chain (IL-4RA), also known as CD124, is a transmembrane glycoprotein expressed on a wide variety of hematopoietic and non-hematopoietic cells. It is a receptor for both IL-4 and IL-13. IL-4RA can complex with the common gamma chain (IL-2R gamma or CD132) and utilizes JAK1 and JAK2 for signal transduction, while complexes of IL-4RA with IL-13RA1 subunit mediate signals via JAK2 and Tyk2. The IL-4 response is involved in promoting Th2 differentiation. The IL-4/IL-13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation.

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