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验证数据展示

  • FC experiment of Transfected HEK-293T using 98180-1-RR (same clone as 98180-1-PBS)

    FC experiment of Transfected HEK-293T using 98180-1-RR (same clone as 98180-1-PBS)

    1x10^6 HEK-293T cells or IL-23R-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human IL-23R Rabbit Recombinant Antibody (98180-1-RR, Clone: 240905B5) and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed. This data was developed using the same antibody clone with 98180-1-PBS in a different storage buffer formulation.

  • FC experiment of Transfected HEK-293T using 98180-1-RR (same clone as 98180-1-PBS)

    FC experiment of Transfected HEK-293T using 98180-1-RR (same clone as 98180-1-PBS)

    1x10^6 HEK-293T cells (left) or IL-23R-transfected HEK-293T cells (right) were surface stained with 0.25 ug Anti-Human IL-23R Rabbit Recombinant Antibody (98180-1-RR, Clone: 240905B5) (red) or Isotype Control (blue), and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed. This data was developed using the same antibody clone with 98180-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98180-1-RR

    Affinity and Kinetic Characterization of 98180-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98180-1-RR against Human IL-23R were performed. The affinity constant is 2.83 nM.

Anti-Human IL-23R Rabbit Recombinant Antibody, PBS Only

IL-23R Uni-rAbTM Recombinant Antibody for FC
Cat No. 98180-1-PBS

产品说明书

CloneNo. 240905B5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

IL23R, interleukin 23 receptor, IL-23 receptor, IL 23R, IL 23 receptor

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98180-1-PBS targets IL-23R in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 23 receptor
别名 IL23R, interleukin 23 receptor, IL-23 receptor, IL 23R, IL 23 receptor
计算分子量72 kDa
GenBank蛋白编号NM_144701.3
基因名称 IL-23R
Gene ID (NCBI) 149233
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ5VWK5-1
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-23 receptor (IL-23R) is a type I cytokine receptor that plays a critical role in immune responses and inflammation. It forms a receptor complex with IL-12Rβ1 and is activated by the cytokine IL-23, which is primarily produced by dendritic cells and activated macrophages (PMID: 39796684). The genetic and epigenetic interactions in the IL-23R/IL-17 axis are associated with elevated expression of IL-17 and inflammatory bowel disease (IBD) pathogenesis (PMID: 21672939).