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验证数据展示

  • WB analysis using 10266-1-AP (same clone as 10266-1-PBS)

    WB analysis using 10266-1-AP (same clone as 10266-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 10266-1-AP (IFNGR2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10266-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 10266-1-AP (same clone as 10266-1-PBS)

    IHC staining of human breast cancer using 10266-1-AP (same clone as 10266-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 10266-1-AP (IFNGR2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10266-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 10266-1-AP (same clone as 10266-1-PBS)

    IHC staining of human breast cancer using 10266-1-AP (same clone as 10266-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 10266-1-AP (IFNGR2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10266-1-PBS in a different storage buffer formulation.

  • IP experiment of A549 using 10266-1-AP (same clone as 10266-1-PBS)

    IP experiment of A549 using 10266-1-AP (same clone as 10266-1-PBS)

    IP result of anti-IFNGR2 (IP:10266-1-AP, 4ug; Detection:10266-1-AP 1:500) with A549 cells lysate 1800ug. This data was developed using the same antibody clone with 10266-1-PBS in a different storage buffer formulation.

  • IF Staining of A549 using 10266-1-AP (same clone as 10266-1-PBS)

    IF Staining of A549 using 10266-1-AP (same clone as 10266-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed A549 cells using IFN-gamma R2 antibody (10266-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 10266-1-PBS in a different storage buffer formulation.

IFN-gamma R2 Polyclonal antibody, PBS Only

IFN-gamma R2 Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 10266-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, IP, Indirect ELISA

别名

IFNGR2, AF 1, AF-1, IFGR2, IFN gamma R2

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

10266-1-PBS targets IFN-gamma R2 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag0317

Product name: Recombinant human IFNGR2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 126-324 aa of BC003624

Sequence: WVTMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIIS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 interferon gamma receptor 2 (interferon gamma transducer 1)
别名 IFNGR2, AF 1, AF-1, IFGR2, IFN gamma R2
计算分子量 45 kDa
观测分子量 50-55 kDa
GenBank蛋白编号BC003624
基因名称 IFNGR2
Gene ID (NCBI) 3460
RRIDAB_2121709
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP38484
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interferon-gamam (IFN-γ) is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of two subunits, IFNGR1 and IFNGR2. IFNGR1 is the ligand-binding subunit which binds IFN-γ with high affinity, whereas IFNGR2 serves as the accessory subunit which attaches to IFN-γ with a significantly lower affinity. Two subunits bind one IFN-γ dimer. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. (PMID: 17981204; 946248; 10888113)

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