验证数据展示
产品信息
87827-1-PBS targets IFNA8 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Eg4954 Product name: Recombinant Human IFNA8 protein (rFc Tag) Source: mammalian cells-derived, pHZ-KIsec-N-rFc Tag: N-rFc Domain: 24-189 aa of BC104830 Sequence: CDLPQTHSLGNRRALILLAQMRRISPFSCLKDRHDFEFPQEEFDDKQFQKAQAISVLHEMIQQTFNLFSTKDSSAALDETLLDEFYIELDQQLNDLESCVMQEVGVIESPLMYEDSILAVRKYFQRITLYLTEKKYSSCAWEVVRAEIMRSFSLSINLQKRLKSKE 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | interferon, alpha 8 |
| 别名 | IFN-alpha-8, Interferon Alpha 8, Interferon alpha-8, Interferon alpha-B, Interferon alpha-B2 |
| 观测分子量 | 25 kDa |
| GenBank蛋白编号 | BC104830 |
| 基因名称 | IFNA8 |
| Gene ID (NCBI) | 3445 |
| RRID | AB_3745773 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P32881 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
IFNA8 (Interferon alpha-8) is a member of the type I interferon family, primarily produced by macrophages and virus-infected cells, and possesses broad-spectrum antiviral activity. This protein exerts its effects by binding to the type I interferon receptor, activating the JAK-STAT signaling pathway, and inducing the expression of various interferon-stimulated genes (ISGs). Studies have shown that the antiviral activity of IFNA8 is significantly higher than that of other subtypes such as IFNA1, playing a crucial role in defending against infections like vesicular stomatitis virus. Furthermore, the transcription of IFNA8 is regulated by the transcription factor Oct-1, and single nucleotide polymorphisms in its promoter region are associated with the prognosis of glioma patients.
