验证数据展示
发表文章中的应用
| KD/KO | See 3 publications below |
| WB | See 5 publications below |
产品信息
51001-2-AP targets ICMT in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | isoprenylcysteine carboxyl methyltransferase |
| 别名 | HSTE14, ICMT, MST098, MSTP098, PCCMT, PCMT, PPMT |
| 计算分子量 | 284 aa, 32 kDa |
| 观测分子量 | 30-34 kDa |
| GenBank蛋白编号 | BC028168 |
| 基因名称 | ICMT |
| Gene ID (NCBI) | 23463 |
| RRID | AB_2122574 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O60725 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Aliquoting is unnecessary for -20oC storage. |
发表文章
| Species | Application | Title |
|---|---|---|
J Clin Invest Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.
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J Cell Biol Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.
| ||
Oncotarget Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells. | ||
Life Sci Alliance NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane.
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J Biol Chem Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor. |