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验证数据展示

  • WB analysis of Jurkat using 17699-1-AP (same clone as 17699-1-PBS)

    WB analysis of Jurkat using 17699-1-AP (same clone as 17699-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 17699-1-AP (ICAM3/CD50 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17699-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 17699-1-AP (same clone as 17699-1-PBS)

    IHC staining of human colon using 17699-1-AP (same clone as 17699-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon using 17699-1-AP (ICAM3/CD50 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 17699-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 17699-1-AP (same clone as 17699-1-PBS)

    IHC staining of human colon using 17699-1-AP (same clone as 17699-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon using 17699-1-AP (ICAM3 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 17699-1-PBS in a different storage buffer formulation.

  • WB analysis of Jurkat using 17699-1-AP (same clone as 17699-1-PBS)

    WB analysis of Jurkat using 17699-1-AP (same clone as 17699-1-PBS)

    WB result of ICAM3/CD50 antibody (17699-1-AP; 1:3000; incubated at room temperature for 1.5 hours) with sh-Control and sh-ICAM3/CD50 transfected Jurkat cells. This data was developed using the same antibody clone with 17699-1-PBS in a different storage buffer formulation.

  • IP experiment of Jurkat using 17699-1-AP (same clone as 17699-1-PBS)

    IP experiment of Jurkat using 17699-1-AP (same clone as 17699-1-PBS)

    IP result of anti-ICAM3/CD50 (IP:17699-1-AP, 4ug; Detection:17699-1-AP 1:500) with Jurkat cells lysate 4000 ug. This data was developed using the same antibody clone with 17699-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

ICAM3/CD50 Polyclonal antibody, PBS Only

ICAM3/CD50 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 17699-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IP, Indirect ELISA

别名

CDW50, ICAM3, CD50, ICAM 3, ICAM R

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

17699-1-PBS targets ICAM3/CD50 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag11955

Product name: Recombinant human ICAM3 protein

Source: e coli.-derived, T-HIS

Tag: 6*His

Domain: 200-547 aa of BC058903

Sequence: GLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMGEEPSRAE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 intercellular adhesion molecule 3
别名 CDW50, ICAM3, CD50, ICAM 3, ICAM R
计算分子量 547 aa, 60 kDa
观测分子量 110-160 kDa, 60 kDa
GenBank蛋白编号BC058903
基因名称 ICAM3/CD50
Gene ID (NCBI) 3385
RRIDAB_2248763
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP32942
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ICAM3 (Intercellular adhesion molecule 3) is also named as CD50, CDw50 and ICAM-R. ICAM3 is a member of the intercellular adhesion molecule (ICAM) family. ICAM3, being expressed constitutively on T cells and other leukocytes, is a potent signalling molecule and a major ligand in the initiation of T cell-mediated immune responses (PMID: 1448173, PMID: 11812993). ICAM3 is the natural ligand for both DC-SIGN and L-SIGN (PMID: 17570115). ICAM3 is abundantly and constitutively expressed in all leukocytes and is probably the most important ligand for LFA-1 in initiating immune responses, and ICAM3 is a typical type I transmembrane glycoprotein (PMID: 39991572). The promoter region of ICAM3 can be bound by co-transcription factors such as ETs and C/EBP, promoting macrophage maturation as well as monocyte extravasation (PMID: 22479382). ICAM3 is widely expressed not only in lymphocytes such as T and B cells but also in many endothelial cells and dendritic cells (PMID: 39991572).

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