Recombinant Human TGFBI/BIGH3 protein (His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human TGFBI protein Gly24-His683 (Accession# Q15582) with a His tag at the C-terminus. |
| 基因ID | 7045 |
| 蛋白编号 | Q15582 |
| 预测分子量 | 73.2 kDa |
| SDS-PAGE | 60-75 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
TGFBI, also named as BIGH3, Kerato-epithelin and RGD-CAP, binds to type I, II, and IV collagens. TGFBI is an adhesion protein which may play an important role in cell-collagen interactions. In cartilage, it may be involved in endochondral bone formation. TGFBI is an extracellular matrix adaptor protein, it has been reported to be differentially expressed in transformed tissues. TGFBI is a predictive factor of the response to chemotherapy, and suggest the use of TGFBI-derived peptides as possible therapeutic adjuvants for the enhancement of responses to chemotherapy.
参考文献:
1.J Skonier, et al. (1992) DNA Cell Biol. 11(7):511-22. 2.J Skonier, et al. (1994) DNA Cell Biol. 13(6):571-84. 3.Narendra Thapa, et al. (2007) Int J Biochem Cell Biol. 39(12):2183-94. 4.Marta Irigoyen, et al. (2010) Mol Cancer. 28:9:130. 5.Miranda P Ween, et al. (2012) Int J Mol Sci. 13(8):10461-10477.
