Recombinant Human Transthyretin protein (His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
纯度 | >90 %, SDS-PAGE |
内毒素 | <1.0 EU/μg protein, LAL method |
生物活性 |
Not tested |
来源 | HEK293-derived Human Transthyretin protein Gly21-Glu147 (Accession# P02766) with a His tag at the C-terminus. |
基因ID | 7276 |
蛋白编号 | P02766 |
预测分子量 | 14.8 kDa |
SDS-PAGE | |
组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Transthyretin (TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition (amyloidosis). Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR),hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) and carpal tunnel syndrome type 1 (CTS1).
参考文献:
1. Iwasaki, Takeshi et al. Neuropathology: official journal of the Japanese Society of Neuropathology vol. 31,6 (2011): 632-8. 2. Sousa, João Carlos et al. Neurobiology of aging vol. 28,5 (2007): 713-8.