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Recombinant Human TGFBR2 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2943

Print datasheet

Synonyms

TGFBR2, EC:2.7.11.30, TbetaR-II, TGF beta receptor type 2, TGF-beta receptor type II

验证数据展示

  • Purity of Recombinant Human TGFBR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human TGFBR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human TGFBR2 protein Thr23-Asp159 (Accession# P37173-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 7048
蛋白编号 P37173-1
预测分子量 41.5 kDa
SDS-PAGE 48-65 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

TGFBR2 is a serine/threonine kinase and the primary ligand-binding receptor. After binding of the ligand TGF-ß1, TGFBR2 forms a heterodimer complex with TGFBR1, causing conformational changes and signal propagation via canonical (SMAD-dependent) and non-canonical (SMAD-independent) routes. Upon translocation into the nucleus, activated SMAD complexes can interact with various transcription factors to control target gene expression.

参考文献:

1. Batlle E., et al. Immunity. 2019;50:924–940.
2. Derynck R., et al. Nature. 2003;425:577–584.