Recombinant Human TF protein (Myc & 6*His)
种属
Human
纯度
>90 %, SDS-PAGE
标签
Myc Tag, His Tag
生物活性
未测试
验证数据展示
产品信息
纯度 | >90 %, SDS-PAGE |
内毒素 | <1.0 EU/μg protein, LAL method |
生物活性 |
Not tested |
来源 | HEK293-derived Human TF protein Val20-Pro698 (Accession# BC059367) with a Myc tag and a His tag at the C-terminus. |
基因ID | 7018 |
蛋白编号 | BC059367 |
预测分子量 | 80.8 kDa |
SDS-PAGE | |
组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Serotransferrin(TF) is a 77 kDa secreted protein which is also named as transferrin, siderophilin, beta-1 metal-binding globulin and belongs to a family of homologous iron-binding glycoproteins that encompasses lactoferrin (found both intracellular and in secretions, including milk), melanotrasferrin (present on melanoma cells) and ovotransferrin (present in egg white). TF is a multi-function protein with a primary role in transporting iron in a safe, redox-inactive state from absorption to utilization or storage sites around the body. The association of Tf with the immune system derives from its ability to restrict serum free-iron levels, creating low-iron environments where the infection capacity of pathogenic microorganisms is limited. TF is expressed predominantly in the liver and secreted in plasma, but lower amounts can be synthesized in other tissues such as the brain and the testis.
参考文献:
1. Weaver, Michael, and Douglas W Laske. Journal of neuro-oncology vol. 65,1 (2003): 3-13. 2. Szőke, Dominika, and Mauro Panteghini. Clinica chimica acta; international journal of clinical chemistry vol. 413,15-16 (2012): 1184-9. 3. Irie, S, and M Tavassoli. The American journal of the medical sciences vol. 293,2 (1987): 103-11. 4. Dufès, Christine et al. Therapeutic delivery vol. 4,5 (2013): 629-40.