Recombinant Human Alpha Synuclein protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Alpha Synuclein protein Met1-Ala140 (Accession# P37840-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 6622 |
| 蛋白编号 | P37840-1 |
| 预测分子量 | 40.5 kDa |
| SDS-PAGE | 10 kDa and 35-68 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Alpha Synuclein (α-syn) is a phosphoprotein that is primarily localize to the presynaptic terminals of mature neurons, where it is involved in synaptic function and plasticity. Α-syn has drawn intense interest ever since the late 1990s, when the first α-synuclein missense mutation was identified as a cause of familial Parkinson's disease (PD). Aggregated and hyper-phosphorylated forms of α-syn protein are the pathological hallmark of Lewy body disease, which includes Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and Lewy body variant of Alzheimer's disease (LBV). This antibody can recognize all the isoforms of α-syn.
参考文献:
1. Spillantini, M G et al. Nature vol. 388,6645 (1997): 839-40. 2. Choi, Insup et al. Nature communications vol. 11,1 1386. 13 Mar. 2020. 3. Singleton, A B et al. Science (New York, N.Y.) vol. 302,5646 (2003): 841.
