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Recombinant Human SMR3B protein (rFc Tag) (HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3081

Print datasheet

Synonyms

P B, PBII, PRL3, PROL3, Proline rich peptide P B

验证数据展示

  • Purity of Recombinant Human SMR3B was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human SMR3B was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human SMR3B was greater than 90% as determined by SEC-HPLC.

    The purity of Human SMR3B was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human SMR3B protein Gln23-Pro79 (Accession# P02814) with a rabbit IgG Fc tag at the C-terminus.
基因ID 10879
蛋白编号 P02814
预测分子量 31.8 kDa
SDS-PAGE 33-38 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

SMR3B is a protein with endopeptidase inhibitor activity and is involved in various cellular processes. It is overexpressed in various cancers and is a potential therapeutic target. SMR3B is predicted to have endopeptidase inhibitor activity. It is involved in cellular response to lipopolysaccharide, negative regulation of peptidase activity, and regulation of sensory perception of pain. It is located in extracellular exosomes. It is overexpressed in various cancers and has pleiotropic effects, leading to cellular characteristics such as sustained proliferation signals, replicative immortality, genomic instability and mutations, resistance to cell death, and angiogenesis. It is predominantly expressed in the salivary gland.

参考文献:

1. Casarin RCV, Salmon CR, et al. (2023) J Clin Periodontol. 50(7):942-951. 
2. Baněčková M, Thompson LDR, et al. (2023) Am J Surg Pathol. 47(6):661-677. 
3. Liu J, Zhao S, et al. (2023) Chin Med J (Engl). 136(2):184-193. 
4. Skálová A, Banečkova M, et al. (2020) Am J Surg Pathol. 44(10):1295-1307.