Recombinant Human SCRIB protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human SCRIB protein Ser700-Leu1200 (Accession# Q14160-3) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 23513 |
| 蛋白编号 | Q14160-3 |
| 预测分子量 | 77.6 kDa |
| SDS-PAGE | 80-100 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
SCRIB encodes a large, 260-kDa cytoplasmic scaffolding protein that comprises a large leucine-rich repeat (LRR) region and 4 PDZ domains that regulate protein-protein interactionsThe loss of SCRIB in malignant tumors suggest that it has potential to be a tumor suppressor. Mislocalization of SCRIB is involved in epithelial-to-mesenchymal transition (EMT) by inducing loss of E-cadherin. Deregulated SCRIB expression induces tumorigenesis in breast and liver.
参考文献:
1. Kapil, Shweta et al. Oncotarget vol. 8,16 (2017): 26515-26531. 2. Hussein, Usama Khamis et al. Aging vol. 12,12 (2020): 11812-11834.
