Recombinant Human Periostin protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Periostin protein Asn22-Gln836 (Accession# Q15063-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 10631 |
| 蛋白编号 | Q15063-1 |
| 预测分子量 | 117.2 kDa |
| SDS-PAGE | 120-150 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Periostin (POSTN, PN), originally named as osteoblast-specific factor 2 (OSF-2), is a 90-kDa secreted protein which is now classified as a matricellular protein. It is present in a wide variety of normal adult tissues and fetal tissues, and has a role in bone, tooth and heart development and function. Studies show that periostin is overexpressed in a broad range of human cancer types, including lung, ovary, breast and colon cancers. Recent evidence reveals that periostin is expressed by fibroblasts in the normal tissue and in the stroma of the primary tumour, and it is required to allow cancer stem cell maintenance.
参考文献:
1. Gillan, Lindsay et al. Cancer research vol. 62,18 (2002): 5358-64. 2. Morra, Laura, and Holger Moch. Virchows Archiv : an international journal of pathology vol. 459,5 (2011): 465-75. 3. Duchamp de Lageneste, Oriane, and Céline Colnot. Advances in experimental medicine and biology vol. 1132 (2019): 49-61.
