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Recombinant Human MOG protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2878

Print datasheet

Synonyms

MOG, MOGIG 2, Myelin-oligodendrocyte glycoprotein

验证数据展示

  • Purity of Recombinant Human MOG was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human MOG was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human MOG protein Gly30-Gly154 (Accession# Q16653-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 4340
蛋白编号 Q16653-1
预测分子量 40.3 kDa
SDS-PAGE 40-50 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Myelin oligodendrocyte glycoprotein (MOG), which is exclusively expressed in oligodendrocytes, is a component of the outer surface of myelin in the central nervous system (CNS). Although a quantitatively minor component, MOG has strong antigenicity. In fact, MOG was initially identified as an immunodominant target for demyelinating autoantibodies in a guinea pig model of experimental autoimmune encephalomyelitis (EAE).

参考文献:

1. Peschl P. et al. (2017) Front. Immunol. 8:529.
2. Litzenburger T. et al. (1998) J. Exp. Med. 188:169–180.
3. Pollinger B. et al. (2009) J. Exp. Med. 206:1303–1316.