Recombinant Human MICB protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human MICB protein Ala23-Asp309 (Accession# Q29980) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 4277 |
| 蛋白编号 | Q29980 |
| 预测分子量 | 58.3 kDa |
| SDS-PAGE | 60-85 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
The MHC class I chain-related B molecule, also commonly known as MICB, is one of the ligands of NKG2D receptor. NKG2D receptors exist in NK cells and CD8+ T cells, which mediate antitumor response and immune surveillance. MICB is expressed by the intestinal epithelium and epithelial tumors as well. MICA and MICB are closely related and functionally indistinguishable. Both are recognized by cytotoxic γδ T cells expressing the TCR variable region Vδ1. In cancer patients, elevated MICB levels correlated significantly with cancer stage and metastasis.
参考文献:
1. Schrambach, Stéphanie et al. PLoS One. 2007;2(6):e518. 2. Groh, V et al. Proc Natl Acad Sci U S A. vol. 96,12 (1999): 6879-84. 3. Feng Q, et al. J Cancer Res Clin Oncol. 2020;146(6):1405-1413.
