Recombinant Human LBP protein (His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human LBP protein Ala26-Val481(Accession# P18428) with a His tag at the C-terminus. |
| 基因ID | 3929 |
| 蛋白编号 | P18428 |
| 预测分子量 | 55.4 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Lipopolysaccharide-binding protein (LBP) is a soluble acute-phase protein primarily produced by hepatocytes and plays a crucial role in the innate immune response to Gram-negative bacterial infections. It binds to lipopolysaccharides (LPS) on the bacterial surface, facilitating the transfer of LPS to CD14 and TLR4 receptors on immune cells, thereby initiating inflammatory signaling pathways. LBP levels increase significantly during infections and sepsis, making it a potential biomarker for these conditions. Additionally, LBP has been implicated in modulating immune responses in various inflammatory and autoimmune diseases.
参考文献:
1. Zhang, Qilun et al. Nature communications vol. 15,1 3213. 13 Apr. 2024. 2. Fang, Mingqian et al. Immunity vol. 56,3 (2023): 620-634.e11. 3. Meng, Leilei et al. Frontiers in immunology vol. 12 681810. 6 Jul. 2021. 4. Yu, Yang, and Guohua Song. Advances in experimental medicine and biology vol. 1276 (2020): 27-35.