Recombinant Human LAMP2/ CD107b protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human LAMP2 protein Leu29-Phe375 (Accession# P13473-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 3920 |
| 蛋白编号 | P13473-1 |
| 预测分子量 | 64.6 kDa |
| SDS-PAGE | 80-110 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
LAMP2 (CD107b) is a Lysosomal membrane glycoprotein. LAMP2 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis. Although LAMP-2 is localized primarily in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane under certain circumstances, e.g., after platelet activation, during granulocytic differentiation and activation, and in some tumor cells. LAMP2 is involved in lysosomal stability and autophagy. This glycoprotein provides selectins with carbohydrate ligands. LAMP2 may play a role in tumor cell metastasis.
参考文献:
1. R Kundra, S Kornfeld. (1999) J Biol Chem. Oct 22;274(43):31039-46. 2. Eeva-Liisa Eskelinen, et al. (2002) Mol Biol Cell. Sep;13(9):3355-68. 3. V Sarafian, et al. (1998) Int J Cancer. Jan 5;75(1):105-11.
