Recombinant Human IL4 protein (Myc Tag, His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
Myc Tag, His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human IL4 protein His25-153Ser (Accession# P05112) with a Myc tag and a His tag at the C-terminus. |
| 基因ID | 3565 |
| 蛋白编号 | P05112 |
| 预测分子量 | 20.6 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
IL-4 is a cytokine produced by CD4+ T cells in response to helminthes and other extracellular parasites. It promotes the proliferation and differentiation of antigen presenting cells. IL4 also plays a pivotal role in antibody isotype switching and stimulates the production of IgE. This cytokine has been applied in the treatment of autoimmune disorder like multiple myeloma, cancer, psoriasis, and arthritis. IL4 has also been extensively applied to inhibit detrimental effect of Th1. It may promote the growth of epithelial tumors by mediating increased proliferation and survival.
参考文献:
1. Bankaitis, Katherine Venmar, et al. Clinical & experimental metastasis vol. 32,8 (2015): 847-56. 2. Hassan, Mir Tanveerul et al. Methods (San Diego, Calif.) vol. 217 (2023): 49-56. 3. Tang, M L, and A S Kemp. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology vol. 6,1 (1995): 11-9.