Recombinant Human IFNA1 protein (rFc Tag)(HPLC verified)
种属
Human
纯度
>90 %, SDS-PAGE
>90 %, SEC-HPLC
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE >90 %, SEC-HPLC |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human IFNA1 protein Cys24-Glu189 (Accession# P01562) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 3439 |
| 蛋白编号 | P01562 |
| 预测分子量 | 45.4 kDa |
| SDS-PAGE | 42-48 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in 0.5M arg, 30mM Tris, pH8.0. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
IFNA1 (IF-alpha) is a member of the Type I IFN (1) family best known for their antiviral activity. It is a key cytokine regulating the activity of B cells, T-helper cells (Th cells), cDCs and natural killer cells (NK cells). IFNA1 induces B cell maturation into plasma cells and immunoglobulin production. IFNA1 plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). IFNA1 was the first cytokine to show clinical benefit in the treatment of certain types of cancer, including melanoma, chronic myelogenous leukemia, and renal cancer.
参考文献:
1. Jeon K, Kim Y, et al. (2023) Front Immunol. 14:1101808. 2. Jiang S, Sakamoto R, et al. (2019) Front Biosci (Landmark Ed). 24(4):790-797. 3. Wang S, Chen SN, et al. (2021) Fish Shellfish Immunol. 117:70-81.
