• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Recombinant Human Haptoglobin/HP protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg0445

Print datasheet

Synonyms

haptoglobin, HP, BP, HAPT, HP2 ALPHA 2

验证数据展示

  • Purity of Recombinant Human Haptoglobin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Haptoglobin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human Haptoglobin protein Val19-Asn406 (Accession# P00738-1) with a His tag at the C-terminus.
基因ID 3240
蛋白编号 P00738-1
预测分子量 47.1 kDa
SDS-PAGE 17 kDa, 36-46 kDa and 55-65 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Haptoglobin (Hp) is an abundant human plasma protein that tightly captures hemoglobin (Hb) during hemolysis. The Hb-Hp complex formation reduces the oxidative properties of heme/Hb and promotes recognition by the macrophage scavenger receptor CD163. The major functions of Hp are to scavenge Hb, prevent iron loss, and prevent heme-based oxidation. Decreased haptoglobin is a marker for hemolysis because haptoglobin levels become depleted in the presence of large amounts of free hemoglobin.

参考文献:

1.Andersen, Christian Brix Folsted et al. (2017) Antioxid Redox Signal.26(14):814-831. 
2.Shih, Andrew W Y et al. (2014) Am J Hematol.89(4):443-447. 
3.Delanghe, Joris R et al. (2024) Crit Rev Clin Lab Sci.61(4):275-297.