Recombinant Human GITR/TNFRSF18 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human GITR/TNFRSF18 protein Gln26-Glu161 (Accession# Q9Y5U5-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 8784 |
| 蛋白编号 | Q9Y5U5-1 |
| 预测分子量 | 40.8 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
GITR is a type I transmembrane protein that contains a cysteine-rich extracellular domain and an intracellular domain that is highly homologous to TNFR family members 4-1BB/CD137 and CD27. GITR is expressed on a variety of immune cells, including regulatory T cells (Tregs), effector T cells (Teffs), natural killer cells (NK cells), B cells, and certain myeloid cells. Activation of GITR can promote the activation, proliferation, and cytokine secretion of effector T cells.
参考文献:
1. Oja, Anna E et al. Immunology letters vol. 222 (2020): 73-79. 2. Wang, Feng et al. Nature communications vol. 12,1 (2021): 1378. 3. Ming, Siqi et al. Frontiers in immunology vol. 12 (2021): 736269. 4. Chan, Sarah et al. Nature cancer vol. 3,3 (2022): 337-354.