Recombinant Human GAS1 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human GAS1 protein Leu40-Ser318 (Accession# P54826) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 2619 |
| 蛋白编号 | P54826 |
| 预测分子量 | 54.9 kDa |
| SDS-PAGE | 55-65 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Growth arrest-specific 1 (GAS1) is a GPI-anchored membrane protein that functions as a tumor suppressor by inducing cell-cycle arrest and apoptosis. nitially identified for its ability to inhibit cell proliferation, GAS1 exerts its anti-tumor effects through modulation of the Sonic hedgehog (Shh) and RET signaling pathways, and by suppressing aerobic glycolysis via the AMPK/mTOR axis.
参考文献:
1. Gobeil, Stephane et al. Genes & development vol. 22,21 (2008): 2932-40. 2. Del Sal, G et al. Proceedings of the National Academy of Sciences of the United States of America vol. 91,5 (1994): 1848-52. 3. Yu, Wenjie et al. Theriogenology vol. 248 (2025): 117597.
