Recombinant Human FLT3LG protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human FLT3LG protein Thr27-Pro185 (Accession# P49771-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 2323 |
| 蛋白编号 | P49771-1 |
| 预测分子量 | 43.6 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
The FMS-related tyrosine kinase 3 (FLT3) ligand (FLT3LG), a growth factor, is mainly derived from lymphocytes in the tumor microenvironment. FLT3LG is predominantly produced by lymphocytes, notably natural killer (NK) cells in mouse and human tumors. It binds to FLT3 on DCs to enhance their differentiation and expansion. Therefore, it may assist DCs in tumor antigen presentation and antitumor immune response. In addition, mature DCs express FLT3 and proliferate massively under the trigger of FLT3 Ligand.
参考文献:
1.Chen, Lihua et al. Journal of inflammation research vol. 15 (2022): 5889-5904. 2.Barry, Kevin C et al. Nature medicine vol. 24,8 (2018): 1178-1191. 3.Pol, Jonathan G et al. Oncoimmunology vol. 9,1 (2020): 1755214. 4.Durai, Vivek et al. The Journal of experimental medicine vol. 215,5 (2018): 1417-1435.