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Recombinant Human EMR2 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

C-rFc

生物活性

未测试

Cat no : Eg2479

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Synonyms

EMR2, ADGRE2, Adhesion G protein-coupled receptor E2, CD312, EGF like module receptor 2

验证数据展示

  • Purity of Recombinant Human EMR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human EMR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human EMR2 protein Gln24-Glu260 (Accession# Q9UHX3-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 30817
蛋白编号 Q9UHX3-1
预测分子量 51.9 kDa
SDS-PAGE 60-70 kDa, reducing (R) condition
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

EMR2 (Epidermal Growth Factor-like module-containing Mucin-like Hormone Receptor 2), also known as ADGRE2, is a member of the adhesion-GPCR family that contains extracellular EGF-like domains. EMR2 contains a total of five tandem EGF-like domains and expresses similar protein isoforms consisting of various numbers of EGF-like domains as a result of alternative RNA splicing. EMR2 is restricted to myeloid cells including monocytes, macrophages, dendritic cells and granulocytes28 and its expression is highly regulated during monocyte/macrophage differentiation.The ligation of EMR2 could increase neutrophil adhesion, migration and anti-microbial mediator production and could enhance the systemic inflammation.

参考文献:

1. H H Lin, et al. (2000) Genomics. 67(2):188-200.
2. Nisha Bhudia, et al. (2020) Sci Rep. 10(1):1004.
3. Chien-Hao Huang, et al. (2016) Sci Rep. 6:38250.