Recombinant Human Complement C5 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human C5 protein Thr678-Arg751 (Accession# P01031) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 727 |
| 蛋白编号 | P01031 |
| 预测分子量 | 34.6 kDa |
| SDS-PAGE | 35-45 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
The complement system is an important effector that bridges the innate and adaptive immune systems. The fifth component of complement, C5, is part of the complement cascade and plays an important role in inflammation and cell killing. It consists of disulfide-linked alpha and beta polypeptide chains but can be cleaved into two active peptides (C5a and C5b) by C5 convertases. Mutations and defects in C5 are associated with severe recurrent infections.
参考文献:
1.Dunkelberger JR, et al. (2010) Cell Res. 20(1):34-50. 2. Gerard C, et al. (1994) Annu Rev Immunol. 12:775-808. 3.DiScipio RG, et al. (1983) J Biol Chem. 258(17):10629-36.
