Recombinant Human CHI3L1/YKL40 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CHI3L1 protein Tyr22-Thr383 (Accession# P36222) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 1116 |
| 蛋白编号 | P36222 |
| 预测分子量 | 66.5 kDa |
| SDS-PAGE | 60-70 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CHI3L1 (Chitinase-3-Like Protein 11), also known as YKL-40 or HC-gp39, is a secreted glycoprotein and a member of the chitinase-like protein family. Although it lacks chitinase activity, it possesses carbohydrate-binding capacity and participates in inflammatory responses, tissue remodeling, and immune regulation. At the mechanistic level, CHI3L1 can activate multiple signaling pathways such as STAT3, MAPK, and PI3K/Akt, and bind to various receptors including IL-13Rα2 and CD44, thereby promoting cell survival and resistance to apoptosis.
参考文献:
1. Song, Yanna et al. Cell reports vol. 43,5 (2024): 114226. 2. Lananna, Brian V et al. Science translational medicine vol. 12,574 (2020): eaax3519. 3. Yu, Wanli et al. Developmental cell vol. 60,12 (2025): 1751-1767.e9.
