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Recombinant Human Cathepsin D protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1053

Print datasheet

Synonyms

Cathepsin D, CTSD, Cathepsin D heavy chain, Cathepsin D light chain, CLN10

验证数据展示

  • Purity of Recombinant Human Cathepsin D was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Cathepsin D was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human Cathepsin D protein Leu21-Leu412 (Accession# P07339) with a His tag at the C-terminus.
基因ID 1509
蛋白编号 P07339
预测分子量 43.4 kDa
SDS-PAGE 43-49 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CTSD (Cathepsin D), also named CPSD, belongs to the peptidase A1 family. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Human CTSD is synthesized as a 52-kDa precursor that is converted into an active 48-kDa single-chain intermediate in the endosomes, and then into a fully active mature form, composed of a 34-kDa heavy chain and a 14-kDa light chain, in the lysosomes. It is a lysosomal acid protease found in neutrophils and monocytes and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease (PMID: 27114232, PMID: 30717773, PMID: 30051532).

参考文献:

1. Vidoni C, et al. (2016). Med Res Rev. 36(5):845-70. 
2. Ashraf Y, et al. (2019). J Immunother Cancer. 7(1):29. 
3. Chai YL, et al. (2019). Brain Pathol. 29(1):63-74.
4. Mijanovic O, et al. (2021). Pharmaceutics. 5;13(6):837.