Recombinant Human Cadherin-6 protein (rFc Tag)
种属
Human
纯度
>80 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >80 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Cadherin-6 protein Thr19-Ala615 (Accession# P55285-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 1004 |
| 蛋白编号 | P55285-1 |
| 预测分子量 | 92.0 kDa |
| SDS-PAGE | 98-125 kDa , reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Cadherin-6 (CDH6/K-cadherin) is a type I transmembrane glycoprotein of the cadherin superfamily, mediating Ca²⁺-dependent homophilic cell adhesion. It is critical for embryonic kidney morphogenesis, neuronal migration, and placental development. CDH6 is overexpressed in ovarian, renal, and gastric cancers, driving tumor progression and metastasis. It is a validated ADC drug target; the CDH6-targeted ADC R-DXd is in phase II/III trials for platinum-resistant ovarian cancer.
参考文献:
1. Shimazui, T et al. European urology vol. 38,3 (2000): 331-8. 2. Osterhout, Jessica A et al. Neuron vol. 71,4 (2011): 632-9.
