Recombinant Human CXCL7/PBP protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CXCL7 protein Ala59-Asp128 (Accession# P02775) with a rabbit IgG Fc tag at the N-terminus. |
| 基因ID | 5473 |
| 蛋白编号 | P02775 |
| 预测分子量 | 34.8 kDa |
| SDS-PAGE | 35-42 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Platelet basic protein (PBP) , slso named as NAP2, CXCL7, or β-Thromboglobulin, derived from its precursor pro-PBP (PPBP), is a platelet-derived growth factor that belongs to the CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2. By post-translational cleavage, this small protein of ∼14 kD gives rise to connective tissue-activating peptide-III (CTAP-III), neutrophil-activating peptide-2 (NAP-2), β-thromboglobulin (β-TG), and two variants of thrombocidin (TC-1 and TC-2). High PPBP expression was significantly correlated with poor differentiation, lymph node metastasis, vascular invasion and advanced clinical stage.
参考文献:
1. El-Gedaily A, et al. (2004). J Leukoc Biol. Mar;75(3):495-503. 2. Kruidenier L, et al. (2006). Gastroenterology. Jan;130(1):127-36. 3. Guo Q, et al. (2017). Oncol Rep. Feb;37(2):1114-1122.
