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Recombinant Human CLEC5A protein (rFc Tag)(HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90%, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg5030

Print datasheet

Synonyms

CLECSF5, C-type lectin domain family 5 member A, C-type lectin superfamily member 5, MDL 1, MDL1

验证数据展示

  • Purity of Recombinant Human CLEC5A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CLEC5A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human CLEC5A was greater than 90% as determined by SEC-HPLC.

    The purity of Human CLEC5A was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90%, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human CLEC5A protein Pro28-Lys188 (Accession# Q9NY25-1) with a rabbit IgG Fc tag at the N-terminus.
基因ID 23601
蛋白编号 Q9NY25-1
预测分子量 45.6 kDa
SDS-PAGE 50-70 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CLEC5A is critical for dengue-virus-induced lethal disease, and interacts with the dengue virion directly and thereby brings about DAP12 phosphorylation. CLEC5A is critical to regulate NLRP3 inflammasome activation in DV infection and that the blockade of CLEC5A would be helpful to alleviate clinical symptoms in dengue patients. CLEC5A has a pivotal function in the activation of multiple aspects of innate immunity against bacterial invasion.

参考文献:

1. Chen ST, et al. (2008). Nature. 453(7195):672-6.
2. Wu MF, et al. (2013). Blood. 121(1):95-106.
3. Chen ST, et al. (2017). Nat Commun. 8(1):299.
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