Recombinant Human CIB1 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CIB1 protein Gly2-Leu191 (Accession# Q99828-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 10519 |
| 蛋白编号 | Q99828-1 |
| 预测分子量 | 47.2 kDa |
| SDS-PAGE | 43-50 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CIB1(Calcium and integrin-binding protein 1) is also named as CIB, KIP, PRKDCIP. It is an EF-hand-containing protein that binds multiple effector proteins, including the platelet αIIbβ3 integrin and several serine/threonine kinases and potentially modulates their function. It regulates platelet aggregation in hemostasis through a specific interaction with the alphaIIb cytoplasmic domain of platelet integrin alphaIIbbeta3.
参考文献:
1. Leisner, Tina M., et al. The FASEB Journal 30.8 (2016): 2640. 2. Wang, Xianwang, et al. Cellular Physiology and Biochemistry 43.4 (2017): 1413-1424. 3. Heineke, Joerg, et al. Nature medicine 16.8 (2010): 872-879. 4. Yoon, Kyoung Wan, et al. Proceedings of the National Academy of Sciences 106.41 (2009): 17389-17394. 5. Zayed, Mohamed A., et al. Circulation research 101.11 (2007): 1185-1193.
