Recombinant Human CD300C protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CD300C protein Gly21-Arg183 (Accession# Q08708) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 10871 |
| 蛋白编号 | Q08708 |
| 预测分子量 | 44.1 kDa |
| SDS-PAGE | 50-70 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD300c is a member of the CD300 family of receptors, which are type I transmembrane proteins expressed in both myeloid and lymphoid lineages and modulate immune responses by their stimulatory and inhibitory capabilities. CD300c, also known as CLM-6, CMRF-35 and IgSF16, is composed of an IgV-like extracellular domain, a transmembrane domain and a short cytoplasmic tail. It is expressed on the surface of monocytes, macrophages, dendritic cells, neutrophils, some T and B lymphocytes. CD300c has been reported as an activating receptor expressed on monocytes and that it has a potential role in inflammatory responses. It has also been identified as a T cell co-inhibitory molecule.
参考文献:
1. Vitallé J. et al. (2019). Eur J Immunol. 49(3):364-374. 2. Jackson DG. et al. (1992). Eur J Immunol. 22(5):1157-1163. 3. Cui C. et al. (2018). Front Immunol. 9:2657. 4. Simhadri VR. et al. (2013). J Innate Immun. 5(4):389-400.
