Recombinant Human KIR3DL3 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human KIR3DL3 protein Gln26-Leu322 (Accession# Q8N743) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 115653 |
| 蛋白编号 | Q8N743 |
| 预测分子量 | 58.3 kDa |
| SDS-PAGE | 60-70 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
KIR3DL3, a member of the killer cell immunoglobulin-like receptor (KIR) family, is an inhibitory receptor primarily expressed on natural killer (NK) cells and a subset of CD8+ T cells. It plays a role in immune regulation by recognizing specific HLA class I molecules, contributing to the balance between immune activation and inhibition. Recent research has identified KIR3DL3 as an inhibitory receptor for HHLA2, a B7 family ligand, suggesting its involvement in immune checkpoint pathways. KIR3DL3's interaction with HHLA2 can recruit SHP-1 and SHP-2 to attenuate signaling pathways such as Vav1, ERK1/2, AKT, and NF-κB, thereby inhibiting CD8+ T and NK cell functions. It is expressed on immune cells infiltrating HHLA2+ tumors from the human kidney, lung, gallbladder, and stomach, suggesting its potential as a therapeutic target for cancer.
参考文献:
1.Trundley AE. et al. (2006). Immunogenetics. 57(12):904-916. 2.Wei Y. et al. (2021). Sci Immunol. 6(61):eabf9792. 3.Campbell KS. (2021). Cancer Immunol Res. 9(2):128. 4.Li Y. et al. (2023). J Adv Res. 47:137-150.
