Recombinant Human CCL13 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CCL13 protein Gln24-Thr98 (Accession# Q99616) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 6357 |
| 蛋白编号 | Q99616 |
| 预测分子量 | 34.6 kDa |
| SDS-PAGE | 36-40 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in 30mM Tris,500mM Arginine, pH 8.0. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CCL13 (MCP-4)is asecreted C–C chemokinethat recruitsmonocytes, eosinophils, and T cellsto inflammatory sites viaCCR2/CCR3/CCR5 signaling. It plays key roles inallergic inflammation,fibrosis, andimmune cell trafficking, linking innate and adaptive immune responses. Dysregulated CCL13 expression contributes toasthma, autoimmune inflammation, and tumor microenvironment remodeling, underscoring its function as both achemotactic mediatorandpro-fibrotic cytokine.
参考文献:
1. Li, Laifu et al. Frontiers in immunology vol. 14 1176639. 19 Apr. 2023, doi:10.3389/fimmu.2023.1176639 2. Mendez-Enriquez, E, and E A García-Zepeda. Inflammopharmacology vol. 21,6 (2013): 397-406. doi:10.1007/s10787-013-0177-5 3. Wang, Dan et al. Experimental dermatology vol. 30,5 (2021): 723-732. doi:10.1111/exd.14293 4. Yanaba, K et al. The British journal of dermatology vol. 162,2 (2010): 332-6. doi:10.1111/j.1365-2133.2009.09507.x 5. Iwamoto, T et al. Rheumatology (Oxford, England) vol. 45,4 (2006): 421-4. doi:10.1093/rheumatology/kei209 6. Hintzen, Christoph et al. Arthritis and rheumatism vol. 60,7 (2009): 1932-43. doi:10.1002/art.24602
