Recombinant Human B2M protein (mFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human B2M protein Ile21-Met119 (Accession# P61769) with a mouse IgG Fc tag at the C-terminus. |
| 基因ID | 567 |
| 蛋白编号 | P61769 |
| 预测分子量 | 38.4 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Beta-2-microglobulin (B2M) is an important component of the major histocompatibility complex class I (MHC-I) molecule that is expressed on the surface of almost all nucleated cells. B2M has been suggested as an emerging biomarker for cardiovascular diseases (CVD), including coronary heart disease (CHD) and stroke, and mortality. B2M also complexes with many non-classical MHC-I like molecules such as CD1, MR1, HLA-E, -F, -G and neonatal Fc receptor that are involved in mucosal immunity, tumour surveillance, immunoglobulin and albumin homeostasis.
参考文献:
1. Berggård, I, and A G Bearn. The Journal of biological chemistry vol. 243,15 (1968): 4095-103. 2. Shi, Fanchao et al. Atherosclerosis vol. 320 (2021): 70-78. 3. Argyropoulos, Christos P et al. Frontiers in medicine vol. 4 73.