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Recombinant Human Angiogenin protein (mFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

mFc Tag

生物活性

未测试

Cat no : Eg1931

Print datasheet

Synonyms

ANG, Angiogenin, ANG 1, ANG I, ANG1

验证数据展示

  • Purity of Recombinant Human Angiogenin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Angiogenin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human Angiogenin protein Gln25-Pro147 (Accession# P03950) with a mouse IgG Fc tag at the N-terminus.
基因ID 283
蛋白编号 P03950
预测分子量 41.8 kDa
SDS-PAGE 39-45 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Angiogenin (ANG), an angiogenic ribonuclease, is a member of the vertebrate-specific, secreted RNASE superfamily. Angiogenin, originally identified as a tumor angiogenic factor, was related with the growth and metastasis of numerous tumors. Angiogenin has been proposed as a permissive factor for angiogenesis induced by other angiogenic factors, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor, acidic fibroblast growth factor, and epidermal growth factor. Angiogenin production and secretion may be stimulated by hypoxia. Increased angiogenin serum levels have been associated with the incidence and severity of several human tumors, including HCC.

参考文献:

1. Miyake M. et al.(2015). Oncogene. 34(7):890-901.
2. Hartmann A. et al. (1999). Cancer Res. 59(7):1578-83.
3. Kishimoto K. et al. (2005). Oncogene. 13;24(3):445-56.
4. Bárcena C. et al.(2015). Sci Rep. 5:7916.