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Recombinant Human ASGR2 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3052

Print datasheet

Synonyms

ASGR2, ASGP R, ASGP R 2, ASGPR 2, ASGP-R 2

验证数据展示

  • Purity of Recombinant Human ASGR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human ASGR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human ASGR2 protein Gln80-Ala311 (Accession# P07307-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 433
蛋白编号 P07307-1
预测分子量 52.4 kDa
SDS-PAGE 58-68 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

ASGR2, or asialoglycoprotein receptor 2, is a gene that plays a significant role in the clearance of glycoproteins from the bloodstream. The receptor is highly expressed in the liver, where it is located on the sinusoidal face of hepatocytes, and is also found in other cell types such as peritoneal macrophages, intestinal epithelial cells, and testis. The serum ASGR2 level is an efficacy biomarker for balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. Gastric cancer cell-invasive activity was significantly decreased with the knockdown of ASGR2, forced expression of ASGR2 promoted invasive activity.

参考文献:

1. Xu WJ. et al. (2024). Front Immunol. 15:1402250.
2. Tanaka H. et al. (2018). Mol Cancer Res. 16(9):1420-1429.